NFKB1 and neoplasm: In such cases, local tumour infiltration profoundly alters bone architecture through cytokine-mediated mechanisms (IL‐6, receptor activator of nuclear factor kappa-Β ligand (RANKL)) and activation of intracellular pathways such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF‐κB), favouring vertebral collapse even in the absence of significant trauma [7, 8, 9].