The objective of this study was to describe the prevalence of GLP-1 RA use and provide baseline, pre-uptake, population-level estimates of major adverse cardiovascular events (MACE, including myocardial infarction, stroke, and cardiovascular death) and mortality among obese adults without diabetes, in the United States (US), using pooled National Health and Nutrition Examination Survey (NHANES) 2011-2018 data. The gene discussed is GCG; the disease is diabetes mellitus.