Ectopic adrenocorticotropic hormone (ACTH) syndrome, one of the most common endocrine paraneoplastic syndromes, is defined as Cushing’s syndrome caused by ACTH secretion from non-pituitary tumors, accounting for 5%-20% of all Cushing's cases [5]. This evidence concerns the gene POMC and Cushing syndrome due to macronodular adrenal hyperplasia.