CCI - Charlson Comorbidity Index; CHF - chronic heart failure; CKD - chronic kidney disease; HFm/r/p - heart failure with mildly/reduced/preserved ejection fraction; IQR - interquartile range; NT-proBNP - N-terminal pro b-type natriuretic peptide; NYHA - New York Heart Association classification; SD - standard deviation. This evidence concerns the gene NPPB and craniofacial microsomia.