SOCS3 and systemic sclerosis: Results of studies investigating the effects of cannabinoids on SOCS-3 expression vary across different cell types and conditions (for example, the selective CB2 receptor agonist, HU-308, facilitated SOCS-3 protein expression in a model of systemic sclerosis, whereas CBD reduced SOCS-3 protein expression in an intestinal epithelium model) (Tian et al., 2024; Koay et al., 2014).