GPT and Hyponatremia: Regarding events of Grade 3 or higher, the rates were: increased ALT (0.89%), increased AST (0.62%), anemia (4.70%), decreased appetite (0.20%), nausea (0.13%), decreased neutrophil count (17.15%), decreased platelet count (1.79%), rash (0.69%), decreased white blood cell count (8.71%), leukopenia (3.18%), hypothyroidism (0.20%), and hyponatremia (0.34%).