In CCH mice induced by BCAS, CZTL (0.15, 0.3, 0.6, 1.2 g/kg, 30 days) improved the spatial learning and memory abilities by upregulating the choline acetyltransferase (ChAT) and α7 subunit-containing nicotinic acetylcholine receptor (α7nAChR); CZTL also inhibited the NF-κB signaling pathway and inflammatory mediators (Wang Z. et al., 2024). The gene discussed is NFKB1; the disease is columnar cell hyperplasia of the breast.