Ginsenoside Rd (10 and 30 mg/kg, ip for 21 days) alleviated CCH-induced learning and memory impairments in BCAS mice, and this improvement was linked to enhanced neuronal survival and increased BDNF expression in the hippocampus and front cortex, with increased p300/CBP and decreased expression of HDAC2. The gene discussed is BDNF; the disease is columnar cell hyperplasia of the breast.