In 2VO rats, BOHXTN (2.5–10 g/kg, 30 days) alleviated cognitive impairment, neuron loss, decreased inflammation by inhibiting IL-1β, TNF-α, cleaved caspase-3, and iNOS by activating the PI3K/AKT and LXRα/CYP7A1 signaling pathways. Here, CASP3 is linked to Cognitive impairment.