With anti-neuroinflammation via TCM, CCH-induced injury to synapses and myelin could be attenuated by maintaining the ultrastructure (Niu et al., 2020a; Huang et al., 2021; Xiao et al., 2024; Wu et al., 2025), and by modulating the related proteins such as PSD93, PSD95, MAP2, etc. (Nie et al., 2016; Huang et al., 2021; Wu et al., 2025). Here, MAP2 is linked to columnar cell hyperplasia of the breast.