For example, there are several manuscripts targeting cholinergic pathway as a protective mechanism against cognitive impairment, the increase in ChAT+ cells (Xu et al., 2009; Kim et al., 2016; Fagerli et al., 2024; Wang Z. et al., 2024) could improve cognitive deficits and modulate neuroinflammation. This evidence concerns the gene CHAT and Cognitive impairment.