Indeed, Xinshubao tablet could rescue hippocampal neurogenesis dysfunction in BCAS mice (Xiao et al., 2024), Icariside II could improve neuron axon regeneration in CCH rats (Liu et al., 2019), Salidroside could promote angiogenesis through the Notch signaling pathway (Zhilan et al., 2025), while Modified Dioscorea pills promoted angiogenesis and microcirculation remodeling through the Ang/Tie signaling (Kuang et al., 2023). Here, TIE1 is linked to columnar cell hyperplasia of the breast.