Therefore, this study not only verifies that ZSQYJDF can synergistically regulate key effector molecules in the Nrf2-HO1 pathway through its multi-component composition but also provides an in-depth analysis of the inflammation-OS interaction network, offering new strategies and an experimental basis for the precise treatment of EMs.It should be noted that this study observed that ZSQYJDF upregulates the expression of NRF2, HO-1, and NQO1 in ectopic endometrium, preliminarily suggesting its potential activation of the NRF2 pathway. This evidence concerns the gene NQO1 and eosinophilia-myalgia syndrome.