Zhenxing Liu et al. reported that LDLRAD4 interaction with Nedd4, an E3 ubiquitin ligase, promotes the proliferation and migration of hepatocellular carcinoma cells (Liu et al., 2017); Yuko Ito et al. showed that non-genotoxic hepatocellular carcinogens cause the downregulation of oncogenic LDLRAD4 in rat livers, which leads to the disruptive activation of TGF-β signaling (Ito et al., 2020). The gene discussed is LDLRAD4; the disease is hepatocellular carcinoma.