MAPT and Alzheimer disease: - Anterior pattern of atrophy more correlating with TDP-43 (entorhinal cortex and anterior hippocampus volumes) - Posterior pattern of atrophy more associated with tau in AD - The ratio between the anterior hippocampus with the parahippocampal cortex as an early marker of TDP 43 beyond amygdala-only pathology in AD - Involvement of MTL in FTLD-tau suggest presence of TDP-43 copathology