Glial cells can contain abnormal aggregates and may play a role in the pathophysiological process, as well as in the extracellular tau deposits, which increase microglial reactivity, a phenomenon also observed in other neurodegenerative diseases (Schwab et al., 1996; McGeer et al., 1997; Verheijen et al., 2018). This evidence concerns the gene MAPT and neurodegenerative disease.