Most studies comes from the ALS research and have shown a significant association between a higher amount of TDP-43 inclusion in ALS patients and a significantly higher amount of TDP-43 in the epidermis and dermis, as well as a higher amount of TDP-43 in the cytoplasm of dermal fibroblasts (Riancho et al., 2020; Romano et al., 2020; Rubio et al., 2022). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.