FTLD-PSP with concomitant tau and TDP-43 pathologies tend to have higher regional tau burden compared to TDP-43-negative ones, and a significant correlation between tau and TDP-43 burden was noted in the occipitotemporal gyrus, suggesting a potential interactive effect in this region (Yokota et al., 2010). This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.