TARDBP and amyotrophic lateral sclerosis: Abnormal conformation in TDP-43 can be observed in several neurodegenerative diseases, such as FTLD and ALS, where hyperphosphorylated and ubiquitinated TDP-43 accumulate as neuronal cytoplasmic inclusions identified during neuropathological examination (Neumann et al., 2007; Rutherford et al., 2008; Meneses et al., 2021), but also in Limbic-predominant Age-related TDP-43 Encephalopathy (LATE), an entity often found in the brains of older adults and present on average in approximately one-third of autopsies of individuals above 85 years old (Wilson et al., 2013; Nelson et al., 2022).