MAPT and argyrophilic grain disease: FTLD-tau is itself sub-classified according to the underlying strain of tau, which includes 3-repeat (3R) tau inclusion like found in Pick’s disease (PiD), 4-repeat (4R) tau pathologies-[CBD, PSP, aging-related tau astrogliopathy (ARTAG), Argyrophilic grain disease (AGD), and globular glial tauopathy (GGT)- or with both three and 4-repeat tau forms (3R/4R) as in PART and tangle only dementia (ToD) (Mackenzie et al., 2011; Neumann et al., 2021; Nilaver and Urbanski, 2023).