The discrepancies between the amount of tau (for example, evaluated with tau-PET scan) compared to the degree of neurodegeneration are called the T-N mismatch (Carlos et al., 2023b), which correlated with non-AD pathology and particularly TDP-43 copathology as proven on neuropathology studies after autopsy (Josephs et al., 2017; Woodworth et al., 2022; Lyu et al., 2024). Here, MAPT is linked to Alzheimer disease.