TARDBP and proteostasis deficiencies: Perry syndrome is another rare form of TDP-43 proteinopathy, highlighting the broad spectrum of disorders associated with this proteinopathy (Wider et al., 2009; Mishima et al., 2018), and is an autosomal dominant neurodegenerative disease caused by a mutation in the dynactin 1 (DCTN1) gene on chromosome 2p13.1 that results in TDP-43 pathology (Ueda et al., 2024).