The experimental schedule and method are shown in Fig. 9A. The KF restored epidermal differentiation proteins such as filaggrin and involucrin that were lost by AD cocktail treatment in the RHS model (quantifying recovery efficiency, KF 20 and 40 μM: filaggrin, 79% and 83%; involucrin 69% and 100%) (Fig. 9B) and showed similar results at the gene level (quantifying recovery efficiency, KF 20 and 40 μM: filaggrin, 32% and 101%; involucrin, 18% and 85%) (Fig. 9C). This evidence concerns the gene IVL and Alzheimer disease.