In addition, it was found that the levels of AD-related cytokines tnfα, tslp, and il6 increased by AD cocktail were dose-dependently down-regulated (quantifying recovery efficiency, KF 20 and 40 μM: tnfα, 32% and 101%; tslp, 18% and 85%; il6, 33% and 78%) (Fig. 9D), and the lost ho-1 and ahr gene levels were restored (quantifying recovery efficiency, KF 20 and 40 μM: ho-1, 80% and 139%; ahr, 68% and 188%) (Fig. 9E). The gene discussed is HMOX1; the disease is Alzheimer disease.