In addition, in the actual RHS model, KF was able to confirm the result of alleviating the thickness of the epidermis and dermis layer thickened by AD induction (quantifying recovery efficiency, KF 20 and 40 μM: dermal thickness, 25% and 104%; epidermis thickness, 10% and 89%) (Fig. 9G), which can be seen as strong evidence for the AD regulation effect of KF through AhR shown previously. The gene discussed is AHR; the disease is Alzheimer disease.