According to the top 20 targets based on the degree-method-generated PPI network along with the close-to-probability-1 targets retrieved from the SwissTargetPrediction database, the final targets to investigate anti-AD were identified, including ABCB1, CA2, ALOX5, CA12, and AhR (Fig. 1D and Tables S3 and S4). This evidence concerns the gene CA2 and Alzheimer disease.