AHR and Alzheimer disease: In addition, in order to compare the specific affinity for KF for AhR, which was discovered as the AD target of KF, we measured the binding affinity to tapinarof, a representative natural-product-derived treatment currently used for AD or skin inflammation, and the measurement results were as follows: A lower result than that of KF was confirmed with a binding force of 7.1 kcal/mol (Table S6).