TMPRSS2 and adenocarcinoma: This action caused a significant decline in SARS-CoV-2 replication in A549ACE2/TMPRSS2 cells (adenocarcinoma human alveolar basal epithelial cells overexpressing ACE2 and TMPRSS2) and in primary human airway epithelial cells (HAE) (Konkel et al., 2023b).