In the case of PD, both strategies have been used indistinctly, however, the first strategy is worth highlighting since it has been used for the analysis of the genes that encode the proteins parkin, PINK1, LRRK2, and α-syn (this last protein being the most studied in this models) (Dunham and Fowler, 2013; Shadrina and Slominsky, 2021). This evidence concerns the gene PINK1 and Parkinson disease.