IL17RC and hypersensitivity pneumonitis: Animal studies have shown that mice receiving IL-17A-neutralizing antibody injection, as well as mice genetically knocking out IL-17 receptor C (IL-17RC KO), resulted in a significantly less severe RID after irradiation.40 Furthermore, Wang et al.68 found that neutralizing the IL-17A signaling by the administration of anti-IL-17A antibodies before exposure to irradiation resulted in a significant reduction in the percentage of grade II and III alveolitis in irradiated mice compared to either the RT alone or placebo groups.