They confirmed that oral mucositis after irradiation in IL-17RA KO mice was associated with a higher density of neutrophils and more severe immunopathological features in oral tissues than in WT mice.44 In addition, while radiation enhanced the expression of the IL-17-related transcriptional genes during the process of RIOM, the lack of IL-17RA in these mice increased the IL-1-mediated recruitment of neutrophils in oral tissues.44 These findings support the protective role of IL-17A against RIOM development in mice. This evidence concerns the gene IL17A and oral mucositis.