Multivariate logistic regression analysis showed that decreased serum APN level, increased Cys-C and D-dimer levels, proteinuria quantification during pregnancy ≥5 g/24 h, and oligohydramnios were independent risk factors for placental abruption in patients with severe pre-eclampsia (all p < 0.05). This evidence concerns the gene ANPEP and oligohydramnios.