PCSK1N and small cell lung carcinoma: Collectively, these differences demonstrate that distinct pathological subtypes of LCBM achieve functional regulation through specific parameter combinations (e.g., “high Vp + high Ve + high Kep” in LUAD-BM; “high Kep + high iAUC90 + low Vp” in SCLC-BM), providing quantitative evidence for deciphering the pathophysiological heterogeneity of LCBM.