In addition, tumor cells evade necroptosis, a RIPK1/RIPK3/MLKL-dependent death pathway, through downregulation of RIPK3 or MLKL expression, or by exploiting molecular chaperones to suppress pathway activation, enabling escape from TNFα family cytokines or certain chemotherapy-induced cell death (75, 76). This evidence concerns the gene RIPK3 and neoplasm.