Pyroptosis, defined as gasdermin-mediated inflammatory lytic death, is also suppressed by tumor cells through downregulation of GSDM proteins (e.g., GSDMD, GSDME) or inhibition of upstream inflammasome activation (e.g., NLRP3), conferring resistance to immunotherapy- or chemotherapy-induced pyroptosis (77, 78). This evidence concerns the gene GSDMA and neoplasm.