AKT1 and gastric cancer: For instance, hsa_circ_0072309 modulates tumor immune infiltration via activation of the PI3K-AKT/Ras pathway (136), whereas circMAN1A2 (hsa_circ_0000118) influences gastric cancer progression by inhibiting CTL secretion of cytokines such as TNF-α and IFN-γ (137).