To investigate whether the expression pattern of keratins in PN-like mouse skin recapitulates that of PN patients, IHC was conducted to assess the distribution of key keratin markers, including keratin 5 (K5), keratin 10 (K10), keratin 16 (K16), and loricrin (LOR) in the skin lesions of four murine groups. Here, KRT5 is linked to poikiloderma with neutropenia.