Furthermore, PN-like mice exhibited pronounced increases in Th17/IL17-associated genes (Ccl20, Cxcl2/3, Lcn2), Th17/Th22-associated genes (S100a8/a9) and Th22/IL22-associated genes (Il1b, Calm5, Ccl7, Cxcl5, Sepinb1a/1b/1c) compared to the EtOH and/or AD-like groups (Figure 6A). The gene discussed is S100A8; the disease is Alzheimer disease.