Our study revealed that canonical Th2 cytokines (Il4, Il5, Il13) demonstrate the highest expression levels in AD-like mice consistent with findings from 14-day AD-like models (47), and followed by PN-like models, while type 2-associated immune cells displayed differential infiltration patterns - macrophages reached peak levels in PN-like mice, with eosinophil accumulation second only to AD-like specimens. The gene discussed is IL4; the disease is Alzheimer disease.