In the BC versus CON classification, LAP-TGF beta-1 emerged as the primary discriminator, achieving an AUC of 0.86 with a 95% bootstrap confidence interval (CI) of 0.69–0.98; the three-protein panel did not significantly improve performance (AUC 0.84, CI 0.68–0.96), with TRANCE and IL-17C performing at chance level (Figure 4, top row). The gene discussed is TGFB1; the disease is breast cancer.