➢ Anti-HBs levels above 300 mIU/mL may interfere with the detection of samples with extremely low viral loads (21).➢ Anti-HBs has a relatively limited lifespan in circulation, but it can be detected in OBI individuals with HBV-DNA and anti-HBc (134).➢ Enhanced anti-HBs levels promote the body’s immune clearance of HBV, reducing the risk of HBV-related cirrhosis and HCC (97).➢ Low viral load seems to be inversely proportional to anti-HBs levels and directly proportional to anti-HBc levels (47, 52). Here, KRT88P is linked to Cirrhosis.