Clustering based on correlation strength identified three major gene groups: Cluster 1 includes genes with weak correlation with CST7. It contains tumor cell associated genes (SOX2, a marker of tumor stem cells, GFAP a marker of astrocytes and differentiated tumor cells, CTSL2 a marker expressed in both tumor and immune cells), and some genes associated with immune activation (KLRK1, coding for NKG2D activating receptor on NK cells, IL12A, promoting Th1 differentiation, LAMP1, involved in the degranulation of cytotoxic immune cells, NOS2, which promotes inflammation). The gene discussed is NOS2; the disease is neoplasm.