This process is highly compatible with the oxidative stress microenvironment of osteosarcoma (81): osteosarcoma cells, due to rapid proliferation, often exist in states of hypoxia and nutrient deficiency, potentially exacerbating cystine-dependent metabolic abnormalities through overexpression of SLC7A11, thereby creating conditions that promote disulfidptosis. Here, SLC7A11 is linked to osteosarcoma.