SLC7A11 and osteosarcoma: Notably, the triggering conditions for disulfidptosis (glucose deprivation and high expression of SLC7A11) significantly overlap with the microenvironment of orthopedic diseases: regions of degenerative changes are often accompanied by local ischemia and hypoxia (22), while osteosarcoma cells commonly exhibit abnormal activation of SLC7A11 to cope with oxidative stress (23).