F2 and Thrombocytopenia: Some studies have reported that NETosis is associated with inflammatory biomarkers such as interleukin-6 (IL-6) and procalcitonin (PCT), dysregulated coagulation responses (e.g., increased D-dimer, prolonged prothrombin time, and thrombocytopenia) and tissue damage (e.g LDH) in patients with sepsis (23–27).