In this context, our findings reveal a clear association between elevated NETs and increased inflammatory burden (i.e., CRP, PCT, IL-6), markers of coagulation imbalance (i.e., D-dimer), and tissue damage (i.e., LDH) at the time of ED presentation, suggesting that NETs could serve as early indicators of a prothrombotic endotype and multiorgan damage in sepsis. This evidence concerns the gene IL6 and Sepsis.