Researchers found that changes to the cystic fibrosis transmembrane conductance regulator (CFTR) protein can affect the movement of Na+ and Cl− in fluid-secreting cells [98,99,100], resulting in conditions such as dehydration, hyponatremia, and hypokalemia [101,102] due to fluctuations in sweat ion concentrations. Here, CFTR is linked to Hyponatremia.