NPPA and Hypertension: It is worth mentioning that other mechanisms induced by excess salt in the diet also contribute to the development of arterial hypertension, including: reduced atrial natriuretic peptide/brain natriuretic peptide (ANP/BNP) production, overactive sodium-hydrogen antiporter 3 (NHE-3), overactive epithelial sodium channel (ENaC), disturbance to gut microbiota, enhanced systemic inflammation and alerted neurohormonal factors [59].