In the mitochondrial (intrinsic) pathway, orbitides and lignans increase the Bax/Bcl-2 ratio, induce cytochrome c release, and activate caspases-9 and -3, leading to DNA fragmentation and cell death in gastric, leukemia, and breast cancer cell lines [6,73,78,79,80]. The gene discussed is CASP9; the disease is breast carcinoma.