In addition, as a capacity related to the prevention of ED as well as other consequent cardiovascular diseases, such as atherosclerosis and ischemia, SAC has been found to induce proliferation and tubulogenesis of progenitors of ECs in vitro with activation of AKT/eNOS signaling cascades, while in vivo, in mouse xenografts and ischemic models, SAC stimulated neovasculogenesis and restored endothelial functions in ischemic tissues [99]. Here, ADCY10 is linked to ischemia.