Upon univariate analysis, CD subtype (p < 0.001), zinc deficiency (p < 0.001), high CRP (p < 0.001), high FCP (p = 0.031), low albumin (p < 0.001), and corticosteroids (p = 0.013) were predictive of IBD-related surgeries but multivariate analysis showed that only zinc deficiency (OR 5.23, 95% CI 1.27–21.45, p = 0.022) and CD subtype (OR 9.38, 95% CI 1.12–78.85, p = 0.039) were independently associated with IBD-related surgeries (Supplementary Table S3). The gene discussed is CRP; the disease is Zinc deficiency.