Primary outcomes included fasting blood glucose (FBG), glycated hemoglobin (HbA1c), homeostatic model assessment for insulin resistance (HOMA-IR), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), adiponectin, physical fitness, and quality of life (QoL). This evidence concerns the gene IL6 and Insulin resistance.