In vitro, LPS-treated Raw 264.7 macrophage-like cells of animal models (cell line derived from a mouse tumor induced by Abelson murine leukemia virus) show elevated NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasome activity, inflammation, and ROS- and NF-κB-mediated apoptosis—effects that can be reversed by irisin treatment [64]. This evidence concerns the gene NFKB1 and neoplasm.