A cut-off of ≥3 points on the FRAIL questionnaire was significantly associated with an increased likelihood of malnutrition (OR: 3.317; 95%CI: 1.456–7.556), whereas BIA-derived measurements such as MM (OR: 0.732), PhA (OR: 0.033), serum albumin (OR: 0.070) and better perceived health status (EQ-VAS) were identified as significant protective factors against DRM (at least, p < 0.05). This evidence concerns the gene ALB and malnutrition.