PIK3CA and neoplasm: Although the effects of DADS on β-catenin need to be verified in vivo, this event is of particular interest because in HER2-overexpressing cells the upregulation of β-catenin increases the activation of HER2 and HER3 [19], whose dimerization stimulates the activation of the PI3K/Akt pathway [49], which is, in turn, involved in tumor malignancy.