ESR1 and breast neoplasm: We first treated the MDA-MB-453 and SKBR3 cell lines, which were ER/PR-negative and expressing diverse levels of HER2 [62], with a lyophilized hydroalcoholic garlic extract containing a mixture of organosulfur compounds such as DAS, DADS, DATS, and resulted efficient in reducing cell growth and invasive potential of breast tumor cells with ER+ and TNBC phenotypes [31,32,38].