KRAS and pancreatic intraductal papillary-mucinous neoplasm: KRAS mutations are also detected in early precursor lesions of PDAC, including low-grade pancreatic intraepithelial neoplasia (PanINs) and intraductal papillary mucinous neoplasms (IPMNs), underscoring their role in the initiation of neoplastic transformation [5].