The observed statistical association between ALDH1A1+ cells and lymph node metastasis, and between p75NTR+ cells and shorter survival of patients with favorable prognosis, suggests that CSC subpopulation in OSCC is a highly dynamic subpopulation showing different phenotypes at different time points of tumor progression, probably with different clinical connotations. This evidence concerns the gene ALDH1A1 and metastatic malignant neoplasm in the lymph nodes.