To understand the relationship between the CXCR2 axis and neutrophils in primary PC tumors, we selectively knocked out (KO) Cxcr2 in KC mouse models, generating the KCC mouse model (Pdx1-cre; LSL-KrasG12D; Cxcr2−/−). The gene discussed is CXCR2; the disease is pachyonychia congenita.