The original study of ESCC [13] subdivided CAFs into four clusters—CAFs1 (CXCL1+/CXCL8−), CAFs2 (CXCL1+/CXCL8+), and CAFs3/4 (MMP11+)—and performed trajectory analysis suggesting that myCAFs-like CAFs3/4 originated from normal fibroblasts through CAFs1, whereas another trajectory arising from RGS5+ pericytes mediated by CAFs2 and CAFs1/CAFs2 ultimately merged with myCAFs. Here, RGS5 is linked to esophageal squamous cell carcinoma.