Although it was often reported that blood samples were collected in the early hours of the day, suggesting adherence to circadian rhythm, a few of the studies provided details on comorbidities, presence of other conditions (e.g., autoimmune diseases), other relevant risk factors (such as smoking or alcohol consumption), or, most importantly, the use of concomitant medications (in addition to ChT or ET examined in the study). The gene discussed is SLC5A7; the disease is autoimmune disease.