A self-reinforcing circuit marked by OGT-mediated O-GlcNAcylation and tumor hypersialylation through ST3GALs drives proteome-wide remodeling and immune evasion, enhancing PD-L1 stability and promoting Siglec-mediated polarization of tumor-associated macrophages (TAMs) [58,94]. This evidence concerns the gene OGT and neoplasm.