Spatially organized modification programs O-GlcNAcylation and citrullination enriched in hypoxic cores, heightened sialylation at tumor–stroma interfaces, and context-dependent phosphorylation at the periphery converge to enforce immune exclusion by suppressing MHC-I display, stabilizing PD-L1, and fostering NET-mediated physical barriers. Here, CD274 is linked to neoplasm.