Legumain (LGMN), a cysteine endopeptidase present in the ECM, and Nidogen, a basement membrane glycoprotein that acts as a bridge between the ECM molecules (laminin-1 and type IV collagen) and binds to integrins, were presented to associate with increased migration and invasion of endometrial tumor cells in vitro [129,130]. Here, LGMN is linked to endometrium neoplasm.