DGAT2 and triple-negative breast carcinoma: Moreover, IRE1α-dependent RIDD activity contributes to lipid metabolic reprogramming in triple-negative breast cancer (TNBC) by directly cleaving DGAT2 (diacylglycerol O-acyltransferase 2) mRNA, which encodes an enzyme critical for triacylglycerides biosynthesis and lipid droplet formation.