Further analysis of inflammatory cytokine expression in oral cancer revealed that periodontal pathogens promoted the expression of cytokines, i.e., IL-6, TNF-α, IL-18, apoptosis-associated granule protein containing CARD (ASC) (up to 6-fold), and caspase-1 (up to 4-fold), while significantly decreasing the level of transcription factor NF-κB, NOD protein, LRR, pyrin domain-containing protein 3 (NLRP3), and IL-1β (less than 0.5-fold). This evidence concerns the gene NLRP3 and lip and oral cavity carcinoma.