These in vitro findings indicate that exposure of oral cancer cells to P. gingivalis resulted in the induction of additional cytokines, enzymes, and bioactive molecules involved in the proliferation, survival, and aggressiveness of oral squamous cell carcinoma, i.e., cyclin D1, TNF-α, MMP-9, and heparanase. Here, CCND1 is linked to oral cavity squamous cell carcinoma.