BCL11B and acute lymphoblastic leukemia: For rearrangements involving MECOM in AML, IGH in B-ALL, and BCL11B in T-ALL, alternative technologies such as FISH (particularly in resource-limited settings), optical genome mapping (OGM), or whole-genome sequencing (WGS), especially long-read sequencing, should be considered, as these aberrations frequently yield false-negative results on RNA-seq panels.