MYC and diffuse large B-cell lymphoma: DLBCL with increased expression of MYC (>40%) and BCL2 (>70%) analyzed through immunohistochemistry (IHC) and that without chromosomal rearrangements of MYC or BCL2 analyzed through Fluorescence In Situ Hybridization (FISH) were defined as Double-Expressor Lymphomas (DELs), while Double-Hit Lymphomas (DHLs) were characterized by rearrangements of MYC and BCL2 and/or BCL6 irrespective of MYC or BCL2 expression [60].