A recently characterized high-risk subgroup in acute lymphoblastic leukemia (ALL) is defined by the IKZF1plus profile, which is marked by the co-occurrence of IKZF1 deletions alongside deletions in CDKN2A/B, PAX5, or the PAR1 region, in the absence of ERG gene alterations. Here, PAX5 is linked to acute lymphoblastic leukemia.