KLK3 and cancer: According to the EAU guidelines, AS should be considered for patients with ISUP GG 2 disease, characterized by, for example, <10% Gleason pattern 4, PSA < 10 ng/mL, ≤cT2a, low disease extent on imaging, and limited tumor involvement in biopsies, defined as ≤3 positive cores with an ISUP GG 2 and ≤50% cancer involvement per core or another isolated feature of intermediate-risk disease combined with low disease extent in imaging and biopsies.