KLK3 and posterior cortical atrophy: However, based on the recommendations of the Canadian consensus group, ASCO and the DETECTIVE study consensus, AS and deferred treatment can also be considered for patients with favorable ISUP grade group 2 PCa (e.g., PSA < 10 ng/mL, low density, clinical stage ≤ cT2a and a low number of positive systematic cores) [10,11].