In contrast, effector components including CD8+ CTLs, CD4+ Th1 helper T-cells, natural killer (NK) cells, dendritic cells (DCs), and pro-inflammatory TAMs eliminate tumor cells through antigen presentation, cytotoxic molecules such as perforin and granzymes, and pro-inflammatory cytokines, including IFN-γ and TNF-α [11]. Here, CD8A is linked to neoplasm.