Traditional biomarkers such as nuclear matrix protein 22 (NMP22), bladder tumor antigen (BTA) Stat/TRAK, ImmunoCyt/uCyt+, and UroVysion fluorescence in situ hybridization (FISH) were designed to detect specific tumor-associated proteins or chromosomal abnormalities shed into urine [8,9,10,11]. This evidence concerns the gene NUMA1 and neoplasm.