SACK1D and neoplasm: Epigenetic remodeling contributes to this prothrombotic niche: hypomethylation of pro-tumorigenic genes such as FAM83D and TNFRSF10A enhances tumor cell migration and endothelial destabilization [86,87], while hypermethylation of tumor suppressor genes like SCAND3 reduces apoptotic clearance of neoplastic clones [88].