In contrast, the group led by Tamotsu Takeuchi, who first reported CTRP6’s role in HCC, found that treatment with recombinant CTRP6 had no effect on cell growth or Matrigel invasion in three diffuse-type and two intestinal-type GC cell lines, nor on the viability of human gastric epithelial cells [36]. This evidence concerns the gene C1QTNF6 and hepatocellular carcinoma.